The balancing act of NEET proteins: Iron, ROS, calcium and metabolism.
Identifieur interne : 000008 ( Main/Exploration ); précédent : 000007; suivant : 000009The balancing act of NEET proteins: Iron, ROS, calcium and metabolism.
Auteurs : Rachel Nechushtai [Israël] ; Ola Karmi [Israël] ; Ke Zuo [Allemagne] ; Henri-Baptiste Marjault [Allemagne] ; Merav Darash-Yahana [Israël] ; Yang-Sung Sohn [Israël] ; Skylar D. King [États-Unis] ; Sara I. Zandalinas [États-Unis] ; Paolo Carloni [Allemagne] ; Ron Mittler [États-Unis]Source :
- Biochimica et biophysica acta. Molecular cell research [ 1879-2596 ] ; 2020.
Abstract
NEET proteins belong to a highly conserved group of [2Fe-2S] proteins found across all kingdoms of life. Due to their unique [2Fe2S] cluster structure, they play a key role in the regulation of many different redox and oxidation processes. In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron‑sulfur homeostasis. Through their different functions and interactions with key proteins such as VDAC and Bcl-2, NEET proteins coordinate different mitochondrial, MAM, ER and cytosolic processes and functions and regulate major signaling molecules such as calcium and reactive oxygen species. Owing to their central role in cells, NEET proteins are associated with numerous human maladies including cancer, metabolic diseases, diabetes, obesity, and neurodegenerative diseases. In recent years, a new and exciting role for NEET proteins was uncovered, i.e., the regulation of mitochondrial dynamics and morphology. This new role places NEET proteins at the forefront of studies into cancer and different metabolic diseases, both associated with the regulation of mitochondrial dynamics. Here we review recent studies focused on the evolution, biological role, and structure of NEET proteins, as well as discuss different studies conducted on NEET proteins function using transgenic organisms. We further discuss the different strategies used in the development of drugs that target NEET proteins, and link these with the different roles of NEET proteins in cells.
DOI: 10.1016/j.bbamcr.2020.118805
PubMed: 32745723
Affiliations:
- Allemagne, Israël, États-Unis
- District de Cologne, Missouri (État), Rhénanie-du-Nord-Westphalie
- Aix-la-Chapelle, Juliers
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Zandalinas</name><affiliation wicri:level="2"><nlm:affiliation>Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Carloni, Paolo" sort="Carloni, Paolo" uniqKey="Carloni P" first="Paolo" last="Carloni">Paolo Carloni</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physics, RWTH Aachen University, Aachen, Germany; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Germany; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Physics, RWTH Aachen University, Aachen, Germany; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Germany; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425 Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Mittler, Ron" sort="Mittler, Ron" uniqKey="Mittler R" first="Ron" last="Mittler">Ron Mittler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA; Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA. Electronic address: mittlerr@missouri.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA; Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. 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Safra Campus at Givat Ram, Jerusalem 91904, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="Karmi, Ola" sort="Karmi, Ola" uniqKey="Karmi O" first="Ola" last="Karmi">Ola Karmi</name><affiliation wicri:level="1"><nlm:affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="Zuo, Ke" sort="Zuo, Ke" uniqKey="Zuo K" first="Ke" last="Zuo">Ke Zuo</name><affiliation wicri:level="3"><nlm:affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Marjault, Henri Baptiste" sort="Marjault, Henri Baptiste" uniqKey="Marjault H" first="Henri-Baptiste" last="Marjault">Henri-Baptiste Marjault</name><affiliation wicri:level="3"><nlm:affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Darash Yahana, Merav" sort="Darash Yahana, Merav" uniqKey="Darash Yahana M" first="Merav" last="Darash-Yahana">Merav Darash-Yahana</name><affiliation wicri:level="1"><nlm:affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="Sohn, Yang Sung" sort="Sohn, Yang Sung" uniqKey="Sohn Y" first="Yang-Sung" last="Sohn">Yang-Sung Sohn</name><affiliation wicri:level="1"><nlm:affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="King, Skylar D" sort="King, Skylar D" uniqKey="King S" first="Skylar D" last="King">Skylar D. King</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Zandalinas, Sara I" sort="Zandalinas, Sara I" uniqKey="Zandalinas S" first="Sara I" last="Zandalinas">Sara I. Zandalinas</name><affiliation wicri:level="2"><nlm:affiliation>Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Carloni, Paolo" sort="Carloni, Paolo" uniqKey="Carloni P" first="Paolo" last="Carloni">Paolo Carloni</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physics, RWTH Aachen University, Aachen, Germany; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Germany; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Physics, RWTH Aachen University, Aachen, Germany; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Germany; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425 Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Mittler, Ron" sort="Mittler, Ron" uniqKey="Mittler R" first="Ron" last="Mittler">Ron Mittler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA; Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA. Electronic address: mittlerr@missouri.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA; Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta. Molecular cell research</title><idno type="eISSN">1879-2596</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">NEET proteins belong to a highly conserved group of [2Fe-2S] proteins found across all kingdoms of life. Due to their unique [2Fe2S] cluster structure, they play a key role in the regulation of many different redox and oxidation processes. In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron‑sulfur homeostasis. Through their different functions and interactions with key proteins such as VDAC and Bcl-2, NEET proteins coordinate different mitochondrial, MAM, ER and cytosolic processes and functions and regulate major signaling molecules such as calcium and reactive oxygen species. Owing to their central role in cells, NEET proteins are associated with numerous human maladies including cancer, metabolic diseases, diabetes, obesity, and neurodegenerative diseases. In recent years, a new and exciting role for NEET proteins was uncovered, i.e., the regulation of mitochondrial dynamics and morphology. This new role places NEET proteins at the forefront of studies into cancer and different metabolic diseases, both associated with the regulation of mitochondrial dynamics. Here we review recent studies focused on the evolution, biological role, and structure of NEET proteins, as well as discuss different studies conducted on NEET proteins function using transgenic organisms. We further discuss the different strategies used in the development of drugs that target NEET proteins, and link these with the different roles of NEET proteins in cells.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32745723</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-2596</ISSN><JournalIssue CitedMedium="Internet"><Volume>1867</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Biochimica et biophysica acta. Molecular cell research</Title><ISOAbbreviation>Biochim Biophys Acta Mol Cell Res</ISOAbbreviation></Journal><ArticleTitle>The balancing act of NEET proteins: Iron, ROS, calcium and metabolism.</ArticleTitle><Pagination><MedlinePgn>118805</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0167-4889(20)30163-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbamcr.2020.118805</ELocationID><Abstract><AbstractText>NEET proteins belong to a highly conserved group of [2Fe-2S] proteins found across all kingdoms of life. Due to their unique [2Fe2S] cluster structure, they play a key role in the regulation of many different redox and oxidation processes. In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron‑sulfur homeostasis. Through their different functions and interactions with key proteins such as VDAC and Bcl-2, NEET proteins coordinate different mitochondrial, MAM, ER and cytosolic processes and functions and regulate major signaling molecules such as calcium and reactive oxygen species. Owing to their central role in cells, NEET proteins are associated with numerous human maladies including cancer, metabolic diseases, diabetes, obesity, and neurodegenerative diseases. In recent years, a new and exciting role for NEET proteins was uncovered, i.e., the regulation of mitochondrial dynamics and morphology. This new role places NEET proteins at the forefront of studies into cancer and different metabolic diseases, both associated with the regulation of mitochondrial dynamics. Here we review recent studies focused on the evolution, biological role, and structure of NEET proteins, as well as discuss different studies conducted on NEET proteins function using transgenic organisms. We further discuss the different strategies used in the development of drugs that target NEET proteins, and link these with the different roles of NEET proteins in cells.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nechushtai</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karmi</LastName><ForeName>Ola</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuo</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marjault</LastName><ForeName>Henri-Baptiste</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel; Department of Physics, RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darash-Yahana</LastName><ForeName>Merav</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sohn</LastName><ForeName>Yang-Sung</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Skylar D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zandalinas</LastName><ForeName>Sara I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carloni</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Physics, RWTH Aachen University, Aachen, Germany; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Germany; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mittler</LastName><ForeName>Ron</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA; Division of Plant Sciences, College of Agriculture Food and Natural Resources and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65211, USA. Electronic address: mittlerr@missouri.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta Mol Cell Res</MedlineTA><NlmUniqueID>101731731</NlmUniqueID><ISSNLinking>0167-4889</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CoiStatement>Declaration of competing interest The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32745723</ArticleId><ArticleId IdType="pii">S0167-4889(20)30163-4</ArticleId><ArticleId IdType="doi">10.1016/j.bbamcr.2020.118805</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Israël</li><li>États-Unis</li></country><region><li>District de Cologne</li><li>Missouri (État)</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li><li>Juliers</li></settlement></list><tree><country name="Israël"><noRegion><name sortKey="Nechushtai, Rachel" sort="Nechushtai, Rachel" uniqKey="Nechushtai R" first="Rachel" last="Nechushtai">Rachel Nechushtai</name></noRegion><name sortKey="Darash Yahana, Merav" sort="Darash Yahana, Merav" uniqKey="Darash Yahana M" first="Merav" last="Darash-Yahana">Merav Darash-Yahana</name><name sortKey="Karmi, Ola" sort="Karmi, Ola" uniqKey="Karmi O" first="Ola" last="Karmi">Ola Karmi</name><name sortKey="Sohn, Yang Sung" sort="Sohn, Yang Sung" uniqKey="Sohn Y" first="Yang-Sung" last="Sohn">Yang-Sung Sohn</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Zuo, Ke" sort="Zuo, Ke" uniqKey="Zuo K" first="Ke" last="Zuo">Ke Zuo</name></region><name sortKey="Carloni, Paolo" sort="Carloni, Paolo" uniqKey="Carloni P" first="Paolo" last="Carloni">Paolo Carloni</name><name sortKey="Marjault, Henri Baptiste" sort="Marjault, Henri Baptiste" uniqKey="Marjault H" first="Henri-Baptiste" last="Marjault">Henri-Baptiste Marjault</name></country><country name="États-Unis"><region name="Missouri (État)"><name sortKey="King, Skylar D" sort="King, Skylar D" uniqKey="King S" first="Skylar D" last="King">Skylar D. King</name></region><name sortKey="Mittler, Ron" sort="Mittler, Ron" uniqKey="Mittler R" first="Ron" last="Mittler">Ron Mittler</name><name sortKey="Zandalinas, Sara I" sort="Zandalinas, Sara I" uniqKey="Zandalinas S" first="Sara I" last="Zandalinas">Sara I. Zandalinas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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